I've reviewed a ton of interfaces over the years. I'm currently using the TASCAM US-4x4, which replaced the audio part of the V-Studio. I was having lots of instability issues with the V-Studio and because I had access to the TASCAM to try out (hey, it's a Gibson Brand), I gave it a shot. I was extremely impressed with the mic preamps and also appreciated that it had a MIDI 5-pin DIN connector.
I then did some tests to see if the specs matched what I thought I was hearing. The results of those
tests are here, and speak for themselves. Note that these are real-world specs - I tested noise with the mic pres up, ditto crosstalk.
Of course, Focusrite makes fine interfaces and every one I've tested over the years worked well. The only issue I ran into was that with the USB interfaces, the +48V phantom power measured around +35V on two units I tested. It appears to remain a problem as someone from Gibson tested one on the floor at a GC, and it was still +35V. However, virtually all condenser mics work fine with +35V so I don't think it's a significant issue.
Some people find the Focusrite mixer applets confusing because there are quite a few mixing and routing options. The TASCAM applet is extremely bare bones - no internal mixer or DSP, just output routing and sample buffers. I was told by TASCAM all the parts cost went into the discrete mic pres, and I believe them. However, they're all Class A which means that USB does not provide enough power to the unit. It requires using an AC adapter so bear that in mind if you expect to be the 4x4 in a portable application involving a laptop.
I've also used the Octa-Capture and really liked the mixer applet, the fact that it could expand the V-Studio, and the auto-level set function (which I think is great). Although quite a few people in these forums have reported stability issues, it worked fine for me as long as I kept on top of the latest drivers.