There are a lot of comparisons on youtube between the line 6 and AxeFX. The AxeFX is a lot more money and I don't easily hear a difference in the amp sims. OK. They sound different but I would have a hard time saying which one sounds better. Heck, I still use my tube amps, so what do I know.
Effect wise, from what I have read, the AxeFX is the best. I would be curious to hear how Helix may have advanced in this area. Again, neither device currently appeals to me but I do like reading about them.
Some day I will probably get tired of dealing my my tubes amps and I will have a device like this.