I tried searching but must not have used the right terminology. I unplug the USB if I know I will be rebooting a bunch, but what a pain.

run your speakers through a mixer or a volume knob.

I use powered monitors, and I turn them on last when starting the computer. If everything comes on at the same time (like via a master power switch) there will always be some component sending a spike down the line and making a loud noise in your speakers. I've never found a workaround, although I'll bet there is some kind of slow-ramp-up voltage regulated switch you could buy, if you were rich.

Volume knob does not eliminate the pops. I'll just get a separate power strip for the speakers. Thanks for stimulating my brain!
 
All set up and ready to rock!

charlyg
Volume knob does not eliminate the pops. I'll just get a separate power strip for the speakers. Thanks for stimulating my brain!
 
All set up and ready to rock!

It will if you turn it all the way down.

Nope, in fact when I started up today's session, I forgot and had to turn it up as it was all the way down. Well, I mean on the interface. It's not real convenient to adjust the vols on the JBL's.

never leave your speakers on between sessions.
that's just a no brainer.
 

Whether or not turning the volume down will save you from pops depends on where the pop is coming from. If it's coming in via the power supply, the only solution is to leave the monitors for last when powering everything up.
 
If you still get pops after that, it's coming from appliances or lightswitches or some other kind of EMI. Best prevention for that is to have all your audio gear on a separate circuit. When I set up my garage as a studio, before the drywall went up I ran a dedicated circuit back to the distribution panel just for audio gear and computers. No pops here, even if I forget to turn the monitors off.

Charlyg - I urge you to keep the monitors off until everything else in your system is running. Either switch them off or -- as you suggest -- put them on a separate power strip and don't send power to them until the system is up. Most of us at home don't have the option of putting our recording gear on a separate circuit, which would only help with interference noises anyway. To solve your issue, LAST ON, FIRST OFF.

I see this is marked as solved...what solved the problem?  The power swicth? Remind me to never buy monitors with a power switch on the back. Seems most are like this. odd isn't it? 
 
Normally if you turn the monitor volume control of your interface right off then there should be no pops on power up. If there is then I would blame the interface. 
In all my years and a dozens of different set ups it's never been an issue if you turn the master volume off. In the old days this was a mixing console. Now it's your interface. I do think some interfaces don't have proper front panel level controls and this leads to people having to spend more money on a special level control box. seems dumb to me.  
Some cheepo power amps did not have soft start but I would think JBL would be good quality and have proper protection and a soft start.