I got my first pair of open-back headphones a couple years ago, and it makes even the best closed-back cans sound like mud.
Sennheiser HD280Pro is still my favorite for tracking, and the ATH-M50s remain my everyday headphones for editing, but no mix is declared "done" until I've tested it on the open-back Sennheiser HD-580s. They are so comfortable that I regularly fall asleep wearing them.
However, I have yet to hear ANY headphones at any price point that I'd consider neutral enough to serve as my sole reference.