To run the US-20x20 USB3 driver, you need Win10.
USB 3.0 is used in the US-20x20 for (24) channels transmission at 192kHz/24-bit. This is not possible with USB 2.0.
USB3.0/USB2.0 Windows 10
USB2.0 Windows 8, Windows 7, OS X Yosemite(10.10), OS X Mavericks(10.9), OS X Mountain Lion(10.8)