I know this is a common issue for people, but I haven't experienced it much until now. I have a dozen or so EastWest instruments and half a dozen vocal tracks (4 takes each, so 24 vocal takes in all) plus a couple regular Midi tracks. Many times when I hit Space to play, I hear a quick loud pop, then only then Midi tracks play. I will do it a few times, and eventually there are no pops and the EW and audio tracks play. Also, whenever I add a new EW instrument, or connect one that already exists, I get a blue message saying the audio engine dropped out unexpectedly. I do have a smattering of effects on some of these tracks, and when I bypass all audio effects, it plays fine. (All effects are out of the box, Sonitus EQ mostly.) I am using ASIO drivers on a new, clean computer. I understand I'm taxing the machine to process all this and that's causing the failures, but my old machine had a slower processor, a less RAM, and a lot of crapware in the background, and I never had this problem for projects of the same complexity. 
 
I suspect the culprit lies in some Preferences settings I had in the old version, ,and now that I'm running a new install, I don't have those settings anymore. Using the dropout troubleshooting guide on the Cakewalk site I have messed around with Playback I/O Buffer Size and Mixing Latency, but since i'm writing this, obviously they did not make a difference. Or I should say they seemed to at first, but shortly after a few successful runs, I get the same problem with the same frequency. Why might this be happening on this much faster beefier machine?

Do some freezing

Thanks. The question is why am I having this problem on this new better computer, when I never had it on my old crummy computer with projects of similar complexity?

I attempted to answer this on your previous thread but you didn't respond.
 
I think your problem might well be due to an insufficient amount of RAM. 6Gb isn't very much in 2015 and attempting to run 20 instances of Play (as indicated in your previous thread) is likely to produce the results you're seeing.

Oops! Thank you for reminding me to update my profile info!! See accurate system info below...
 
Also, I forgot all my old settings are there in my profile! I just matched them and saw the Playback and Recording Driver Mode was set to MME, so I switched it to ASIO. Having no idea what that means, is that going to make any difference?

On new computers, check to see if your hard drive is being heavily accessed. Maybe Windows defender is scanning stuff?

Maybe a wireless card?

Check power options on network cards. Disable battery saving settings.