Did you wipe the hard drive and install Win10 from scratch or was it an actual upgrade?
This isn't a cakewalk issue anyway otherwise you would not need to reboot, this appears to be hardware/drivers or hardware configuration.... You may have already done this but..
Delete AUD.INI (google for details)
Update your display drivers from manufacturers site.
Update your audio interface drivers and firmware (what is it BTW?).
Update your controllers drivers and firmware (e.g. Maschine).
When was the last time you ran Native instruments service center? (which won't update your drivers and firmware BTW).
Test to see if this happens on a new project with no template. If it works then you could be looking at dodgy plugins.
You haven't got some incompatible antivirus running?