I think I can repro...
I've got a template with lots of soft synths, each synth has single midi track, however all the synth outputs are being routed to audio tracks. i.e. Addictive drums, Maschine, Kontakt, Geist. To add to the recipe I've got drum maps for all of these from several controllers.
Last tested a few days ago in Ipswitch Update 1 - working fine.
With JP soon as I start playing, sometimes before, it whites out, and after waiting for a while all I can do is close the program.
I did manage to get it respond better by deleting the drum maps, however I then ran into the single core issue afterwards...