I've had a day to work with this interface and I can't be happier. This is the sort of thing I was hoping to see from Tascam/Gibson/Cakewalk. It works with my other DAW stuff just fine but it will integrate with Cubase on a tighter level.
In addition to being an interface, the software includes a DSP that gives you the ability to run the included plugin's while tracking and provides a mixer so that you can run different mixes directly to the outputs or headphone busses. The VST version of the plugin's give you most of the same functions but don't integrate to Cubase. You also get Yamaha amp models that remind me of the DG series that they made way back. Clean, Crunch, Drive & Lead.
So you get the interface, Plugins for Reverb, Channel strip, Comp and EQ and 4 amp models for around $300 CDN.
Come on Gibson/Tascam/Cakewalk, this is where you need to go.