Well, if it was me, I'd use that massive external just for backups.
Install another Hard drive or 3 in your pc.
OS, & programs on your C drive
Cakewalk projects on one of your new internals and if you run a fair number of sample libraries, move these onto yet Another drive.
Or, if your current OS is on an SSD, consider if it's big enough to house your sample libraries as well for best performance