Just use a quality? pitch shifter on the offending track or Sonar's real nice radius offline transposer.

slartabartfast

Beepster
Since you are tuning the ENTIRE guitar track you should be able to do this even in the basic version of Melodyne (it does not require the more advanced Polyphony feature). 

I have not used Melodyne, but I do wonder what polyphonic means in this context. I expect that the algorithms that work well to re-tune a true monophonic source (like a single voice) would not work so well it there is a chord playing, even on the same instrument.

 
Melodyne Essential can pitch-shift polyphonic material, just like the Transpose DSP function but without being restricted to semitone intervals. The difference compared to Editor is that Essential can't pitch correct individual notes within polyphonic material.
 
To do basic pitch-shifting, you choose the Percussive algorithm in Essential and all the "blobs" (which can represent chords, program material, etc.) appear on one line, without any particular pitch attributes. You can then turn off Snap, select all blobs, and transpose up or down as desired.
 
Even with Essential, you can even do things like create new chord progressions from a rhythm guitar part - I wrote an article about how to do this for Guitar Player magazine.
 

An aside about Melodyne Editor: The most mind-boggling example I've had of its near-magical qualities was when I did a slide guitar part and the slide ended up at an angle, so the notes on the top strings were a little sharp, the notes in the middle were on pitch, and the notes on the bottom strings were a little flat. Melodyne Editor was able to correct this, which pretty much blew my mind.

thedukewestern
I recently got a few tracks to put some vocal ideas on - however - I've found that the original track has guitar in drop d - however the overall tuning of the track is somewhere between d and e flat - I first heard this - but then opened up a small portion of just the guitar in melodyne to make certain I wasnt crazy.  So - how would you adjust melodyne so that it detects the real tonal center of something that may be not necessarily at 440....   and then snaps to the grid of that new tonal center.

I don't use Melodyne much but I think it does it for you. If you look at the bar(column) farthest left in Melodyne in melodic mode it will tell you the pitch center such as A440 then it will tell you the detected center. I believe if you click the detected center it will then do its tuning based on that. Again,I don't use it very much so I am not saying this is fact, just how I believe it works.

Anderton
An aside about Melodyne Editor: The most mind-boggling example I've had of its near-magical qualities was when I did a slide guitar part and the slide ended up at an angle, so the notes on the top strings were a little sharp, the notes in the middle were on pitch, and the notes on the bottom strings were a little flat. Melodyne Editor was able to correct this, which pretty much blew my mind.

I use Editor to successfully fix fiddle double stops and pedal steel tracks.

I've been using Celemony since Cre8. I use it daily and couldn't do business without it.

A few weeks ago this happened to me when I was messing with AC/DC's "Highway to Hell." That song is roughly 40 cents flat. As mentioned above two options would be to adjust the original or adjust my tuning. A neat site I found in the process of mucking around was this, and using HWTH as an example, if you put "-40" cents in the upper left box it will give you the frequency ratio of 0.97716.

1. To adjust the track I would probably use Audacity (provided all parts are tuned the same), but I did not choose this route. Audacity allows simply inserting a new sample rate (pitch shift) on the track, so if at 44.1KHz, could use 44.1KHz/0.97716 or 45.13KHz to bring it up to 440 tuning. Edit: I just downloaded Audacity since I have not used it in forever. Audacity has an easy adjustment to change pitch without tempo (Effect->Change Pitch... and put cent adjustment in (top) or percentage adjustment in (bottom) of that pop-up window). For the HWTH case, 0.40 in the top adjusted the song to 440 tuning.
2. Adjust the tuning (what I chose). With a chromatic tuner I can simply tune -40 cents across the board, but when using Melodyne it would equate to 440*0.97716 or 429.95 (430Hz) which for me matched the original recording well enough to work with the original recording as a guide track. I actually used 430 for tuning on my Korg CA-40 tuner, since tuning to -40 cents is rather difficult on that (or any that I have used).