Hey guys and thanks for all your great responses, if nothing else it's helped me establish a little more faith in everything I've already tried as I've been down most of these routes but have done some again this morning to try further.
So to start with I have now as Robert_E_Bone suggested removed the additional graphics card and back on the integrated graphics form the APU.
I also disconnected all USB devices apart from my keyboard and mouse, disconnected the USB 3.0 ports from the motherboard and the front panel audio as suggested by sanderxpander. Never had the ASIO4ALL on this setup so that's fine and all drivers up to date with all power limitations turned off.
Shambler, I shall have to read up on this but in the year and a half I've had this setup I've not been able to find anything concrete on this mobo and DAW issues. The search goes on.
PoetnProphet, the current project I'm loading whilst testing this is 6 tracks and only around 1 minute in length. 4 audio tracks, 2 instances of mini grade by AIR music VST. On these I have the 4 audio tracks going to a drum bus with one instance of Breverb and then the instances of piano go to a bus running Valhalla Shimmer. I have looked over optimization guides many times and seem to have followed to the letter but can't hurt to run through some again.
Rbecker, again I shall look over the optimization guides but I've taken this pretty far already, the actual PC boots in seconds and runs lovely, just seems to struggle with the audio mainly.
35mm, I am using the ASIO driver and for testing purposes with the small project (see above) I'm currently working on I have the buffer size at 256, 44.1kHz. Background processes are pretty much non existent, even Windows own CPU monitor within task manager (which always seems high) shows my CPU at 1% occasionally 2% even whilst running this Google Chrome window. I can certainly try another DAW, I shall re-install the Pro Tools free version and test this again as I can't remember how it behaved with the Line 6 and never tested on the Focusrite.
Thanks gswitz, I shall take a look over your video.
Once again guys, I'm so thankful for your assistance. This whole process and this rig has tested my patience and ruined my creativity these last few months so all the help is really appreciated. I shall keep trying and report back.
Thanks