How do you deal with dust?  What a PITA this is.  Anybody use those mini dust vacuums, or is there a better way?

If it is a regular issue, consider getting an electric air cleaner that ionized particles before fanning them past negatively charged plates. Sixty dollars USD usually.

It's not a huge problem.  Just trying to find the easiest way to clean up short of uncabling, moving everything then recabling.
 
Air cleaner is a good idea though

I worry most about dust accumulating on my monitors, especially the folded-ribbon tweeters ADAM uses. I really don't know if dust has any sonic effects, but I throw a couple of towels over the speakers if I'm going to be away for more than a day, just in case.
 
I would not be comfortable vacuuming them. Although the woofers can be safely wiped (gently) with a cloth I haven't figured out any way to clean the tweeters.

Damp cloth always in use here. That, and an artists paintbrush for mixer sliders and keyboards.

I dust nearfield speakers using a (genuine) sable-hair artist's paint brush applied very gently along with a bulb "puffer" of the kind used to blow dust off camera lenses. Guitar speakers get done using short bursts froma can of air duster applied from about a foot away so the air isn't at sub-zero temperatures when it hits.

Though if a little dust does make a difference to the audio I'll admit I can't hear it.

I use makeup brushes on guitars, delicate speakers and around controls and such.  I think I'll try out a battery operated PC keyboard vac on MIDI controller, mixers and such.
 
I just feel like I'm pushing dust into cracks sometimes ... now that my audio interface and S-Plat are working so f-in' great, it's time to concentrate on the small stuff  

I use one of these, very gentle http://www.amazon.co.uk/P...RTER-KIT/dp/B0040DD8LG

 
Open the windows and blow the dust elsewhere with a vacuum cleaner hooked up backwards with a narrow attachment.  Well, maybe not for a ribbon tweeter.  For things that can handle it, like my mixer or a keyboard or monitor, I use the vacuum cleaner the right way around with the long-haired round brush attachement.
 

Humidifiers are useful for dry climates and will help keep the dust down (water traps dust effectively). Followed by using a HEPA/CRI certified vacuum cleaner for the rooms --- cheap vacuum cleaners without good quality HEPA/CRI certified = may as well be using a leaf blower 
 
Air-Filters/Purifiers/Cleaners/Washers (lol, so many weird choices) will reduce dust but the issue is noise, noisy even at low fan speeds or quiet enough when new until it gets old (about 6 months to a year or so).  Good quality (quiet, reliable) are expensive and then there are options for permanent or replaceable filters.  I have central air (for winter and summer) it uses a HEPA filter, it needs to be changed at least every 6 months ($20) which is okay I guess.
 
When my system and other hardware is not in use for a while I turn everything off and cover it all with black leatherette.  Kinda feels like I'm tucking them all into bed, then say a brief bedtime story and kiss 'em all goodnight
 
Computer/hardware cleaning:
I clean once a week (exterior, and dust filter) and once a month or so cleaning (internal) good clothes and soft brushes will do fine especially since there should not be as much dust to begin with (with all of above suggestions)!