Every now and then I will go around in circles for ages in Guitar Rig, TH3 and Amplitube, trying to get a good sound and failing. And then I'll remember I have GTR and boom, it sounds great. I actually like the sound of it for cleanish tones.
However, I mainly use it for amplifying synths. I don't know why but it's just great for that. Just stick it on a synth withthe default setting and it adds some subtle grit that doesn't sound too dirty like I find when putting synths through other amps. And it's great for getting a quick and easy stereo sound.