It has taken me some time to get things dialed in, but I have both my laptop and desktop all set up now.
A few small things that helped...
-- power options ~ high performance
-- Power Options > Advanced > USB Selective Suspend Disabled
Windows Explorer > Right click 'This PC' > Manage > Device Manager >
-- double click network adapter > Power management > Uncheck allow computer to turn off this device.
-- disable webcam
-- disable USB display adapters
-- System Devices > disable High Def Audio Controller (this is a tip from Craig... might not be necessary).
-- Under sound, disable items you don't use.
Install Latency Monitor from Resplendence and check the results.
That said, I'm still getting clicking when switching between applications that use audio.