I've used Avast for about 5 years, now, and it wasn't a problem for me with X3. I'm surprised to hear some were having problems with it and their X3 install. I think it's a great choice for an A/V program (the free or premium version). I also installed SONAR Platinum without any issues from Avast. And my thanks to Cakewalk for the extended trial of SONAR Platinum!
Microsoft Security Essentials can't be installed on Windows 10. Windows Defender was converted into Security Essentials, in Windows 10. Moreover, when another A/V besides Windows Defender is installed in Windows 10, Windows Defender is automatically turned-off.