I had a Saffire Pro 40. It was my first real audio interface unit and I started using it with Sonar 8. It died out of warranty and the estimate cost to repair it was within $50 of what it cost new and it was dumped. The Saffire Pro 40 is sensitive to what Firewire chipset is in the PC and works best (maybe only) with a T.I. chipset as it has a DICE II chipset in the Saffire Pro 40 and DICE/DICE II want a T.I. chipset in the PC.
I liked the preamps in the Saffire Pro 40 but best (reliable) latency I could get was 11ms. With the Octa-Capture (and now Studio-Capture) I'm in the 4 to 6ms range.
I replaced the Saffire Pro 40 with a Roland Octa-Capture. The preamps were different but after using it for a while, I now have to say the Saffire Pro 40's preamps tended to slightly "color" the signal, where the Octa-Capture does not alter the input sounds. For example, my Pedal Steel guitar signal (which is a "clean" signal - no effects or overdrive) tended to have a slight high freq roll off (like the Treble control on an amp was turned down) with the Saffire Pro 40. With the Octa-Capture, what is recorded is exactly how the guitar sounds. I also like the built in (user selectable) limiters and compressors in the Octa-Capture. Also the Octa-Capture has reverb available for the monitor (not for recording) that the Saffire Pro 40 did not have.
I just bought a Roland Studio-Capture as some times I need more than 8 channels and the preamps are supposed to be the same as the Octa-Capture. I did some tracking for the first time yesterday with the Studio-Capture and the recorded sound is exactly like the Octa-Capture.