Do you have your power options for your usb hum to always on (if your using the usb for the midi connectiion)

 
Good tip, I forgot to check that.  I already have the Windows power set to "high performance" but maybe the USB drivers don't know that?  I don't know, I'll give it a try.  I actually have two Oxygens, one's an older Oxygen 8 and I know the drivers don't play very nice together.  I hadn't gotten around to dealing with it yet since technically everything works (with some encouraging).  It's actually the 61 that seems to flake out while the older one has been pretty solid.  Meh.

My M-Audio Keystation Pro 88 does this randomly on any day with a "y" in it. RPITA.

I have lots of open MIDI ports via my MIDISport 8x8 which I'd really prefer using (if only to cut down on USB driver headaches) but it's so convenient powering my keyboards via USB.  Plus, I can't find the power transformers for either one of them.  Bleh.
 
Interestingly, I just added a Korg nanoPAD2 to my gear.  It was a royal PITA to set up, also.  What nobody tells you is that the nano controllers won't work if there are more than 10 MIDI drivers in your system (whether they're being used or not).  Luckily Korg has a utility that lets you uninstall those extra MIDI drivers, and I found multiple instances of all my M-Audio drivers to remove.  Things have worked okay since then, including the nanoPAD2.  Might be a trick that works for the M-Audio stuff too, I don't know.  We'll see.
 
I also stumbled across a thread that mentioned some "M-Audio USB Fix" program, but I could find no specifics on what it was, what it did or where it could be found.  Anybody heard of that?

I'm 3yrs late on this discussion but I have never had a problem with my axiom. But I have drums that lose connection. I have to turn off back on and it will happen again in in 5min..would it possibly be the case my Yamaha drums consum more power? Mind u I have no powere supply to my m audio but I do with my drums. Does this matter?

notsuh100
I'm 3yrs late on this discussion but I have never had a problem with my axiom. But I have drums that lose connection. I have to turn off back on and it will happen again in in 5min..would it possibly be the case my Yamaha drums consum more power? Mind u I have no powere supply to my m audio but I do with my drums. Does this matter?

Have you disabled USB power management?  For specifics, see explanation under Windows Optimizations:
 
https://www.cakewalk.com/Support/Knowledge-Base/2007013376/Windows-Optimization-Guide