The only thing I've done (to every version of Win 10) is set the Power Plan to High Performance and disable fast start up.  
 
 

But for security. do you trust Windows OneDrive for backup or do you use local backup?
 
For me I use both with redundancy.
I use OneDrive for backup, but it is only connected to a backup drive I have on the computer.
So I have:
C: Windows (500 GB m.2)
M: DAW files (1 TB SSD)
O: OneDrive (Normal Harddrive)
 
I only backup files to the OneDrive folder when I’m not working. But I also got a online backup program with unlimited storage. It is synchronizing/backing up as soon as the file is stored on the drives/folders I have set up for backup. It is just 2 click to turn it on pause, if I need to. But turning of the hibernating and so on had a greater impact on the latency.

Cakewalk was fine here after updating Windows 10 with the Windows 10 April 2018 Update.
A few days later, I cleanly installed Windows 10 with the Windows 10 April 2018 Update (ISO) and no problems. 

Good. What tweaks did you do after installing Windows from ISO?

I do full OS drive backups (disc images) with Macrium Reflect (free version).  I also do backups, after a recording session, of a Cakewalk project (manually by copying the Session folder to a backup drive).
 
I have One drive disabled and do not use any cloud based backup.  I'm "old school" having worked in my day job as computer tech/manager since "BPC" (Before PC's).
 
 
 
 

Jarsve
Good. What tweaks did you do after installing Windows from ISO?

I haven't done any tweaks, really. Just reinstalled my usual software and drivers, etc.