Starting with X3 there is no need to configure an effect and a synth.
Select "Enable MIDI Input" in the VST2/3 drop down in the plug-in header.
Add a MIDI track, input set to your controller, output to the plug-in.
Set Echo on the MIDI track
Enable MIDI Learn in the Plug-in, train the plug-in, turn learn off.
Act is another way to control plug-ins. My controller is to anemic to use ACT.
Remote control w/ an automation lane is the third way, I describe it here
http://forum.cakewalk.com/FindPost/3272043