Once you have calibrated your VU meters then they will tell you a lot. Don't forget if you pull the Drive slider down you are not pushing hard then into an analog console buss. e.g. cleaner sound. Same with the Glue control. Back it down and less compression takes place, e.g. more dynamic mix.
Everything on zero as he says is a good setting too and sounds pretty nice to me. Then it is just a matter of fine tuning to taste.
If your mix is nicely balanced tone wise you won't need any Bass or treble fiddling much. They do work well though.
Another forum member
(on another CLA thread) did not like the sound of the drive control all the way up and I agree on a whole mix it may not be smart. But then again on just a slightly distorted guitars buss it could be just the ticket to drive them all a tad harder.
This sounds like it could be a nice plug to mix into as well. It does not replace mastering either. It is somewhere in between a fully unmastered or pre mastered mix and a fully mastered mix. It is something that would help you achieve a very loud master later on if that what was you were aiming for.
Scheps Parallel Particles is also a great plugin and would be really good say before CLA. A lot of control over the EQ or tone of your mix followed by CLA.