I had a little Windows 10 and audio adventure, but it turned out I wasn't running the latest version and it was causing a SHsss sound to occur over and over again. I upgraded them, re-authorized, and my system now makes noise I caused, :-)
If you have any trouble on the otherside of the upgrade, check for the latest versions. I haven't had any driver issues at all. still running Win 7 drivers for all the hardware, although MOTU said they might be releasing W10 drivers this week. No promises though.