That's the kinda thing I'm a bit leery of.
And Jonesey, I really dunno, some of my projects are a little large but probably not as large as yours were. My AMD 8core CPU is outta the box rated at 433, and I'm toting 32GB of RAM. Dunno why I'm getting frequent audio dropouts, and white screen crashes. Did it this morning while trying to add a lead line to a project with only four audio tracks and two MIDI. Each track was sporting at least two fx plugins if I remember correctly. Now one of the commonly used plugs on the piece was Eventides 'Ultrachannel'. Kind of a big plug, dunno if it's the culprit, although the Alchemy player soft synth (Camel Audio) is kinda big too but not huge. It crashed on me three times before I got it to finally take.
Maybe it's the same problem my grandpa used say with my hotrod woes, "probably the nut behind the wheel!"