Allthough failing connections to external HDDs can most likely cause this message, that's not the (whole) answer, neither is the USB2/3 thing.
This false message was familiar before there was USB3, and as the posts verify, both with internal and external
HDDs.
I have never read about it happening with SSDs, though. Of course, that doesn't prove anything, because SSDs are
so new and this issue is not very common anyway.
Greatrockgod ( I like modesty :o), it's a bit weird that archiving tracks made saving possible again, as archiving does not reduce the size of the project.
I wonder if VSTs in demo mode could do this? Many of them are "save disabled". Could such a feature affect the whole project??