Sometimes the Permissions (as in who/what program) can actually access and modify data in a folder in the C Programs drive is blocked....security default is to have editing disallowed for some.
Anyhoo I got it (Melodyne) running again, but ONLY after uninstalling it, doing a VST reset and rescan in Sonar, then re-installing Melodyne and then doing a VST re-scan in Sonar. So yeah its working but I am not going to mark the thread Solved, as the underlying issue is not really solved.
Why does Melodyne magically disappear and can only be re-instated by going through various hoops?