It can't be SONAR because the program does not generate any sound on its own. It has to be something related to SONAR interacting with hardware.
Maybe it's USB picking up "hash" from the USB bus, which usually has all kinds of crap on it. I assume you're not using a hub, powered or otherwise. If so, try a direct connect to the motherboard.
I've had enough issues with some older interfaces that I bit the bullet and installed a USB PCI card in my computer and use it only for devices that pass audio. That solved a bunch of problems. The "dirty" USB devices, like hard drives, go to the motherboard's ports.
Finally, try connect a wire between the interface ground and the computer's ground to determine if there's a change in the character or level of the hum. Also, by hum I assume you mean sine wave 60 Hz hum, not something with harmonics.