I used to run Win 7 x64 with Sonar x64 on 8GB which was totally fine for most applications, even 50+ tracks of heavy mixing with Steven Slate VCC etc.
When I started doing large-scale composing for TV I got frustrated with popping and latency when there are a bunch of synths open, and now I run 24GB. I don't think the indicator has ever showed more than 8GB in use, but I can keep 30 - 40 synths live with samples loaded and still get killer performance plus no latency.
My PC is only an i7 2600 (about 4 years old) with 1333 DDR3 RAM so I'm sure those numbers can improve tremendously by now, esp with faster bus speeds.
HOWEVER, the quality of your soundcard drivers may well make a huge difference too. I'm spoilt with RME :O)