Soft synths and FX plugins load your CPU (and RAM) while audio tracks (without FX) load your hard disk. Overloading either can cause a dropout, but disk dropouts are generally less of a problem. Both can generally be prevented by setting appropriate buffers, and, as Johnny pointed out, making sure your DPC latency is low and, most importantly, stable with no spikes.
Crashes are another issue altogether, and generally don't happen due to high CPU/disk loading alone (although high loads can voltage sags that lead to instability). If you have any defective RAM, a big project plugin-heavy project is more likely to expose it, so running MemTest or similar to check you RAM is a good idea when you're seeing a lot of instability. In general, though, crashes are due to software/firmware code errors or interoperability issues among plugins, SONAR, the O/S and hardware interfaces.
Having a high-performance machine like yours should help prevent dropouts, but doesn't guarantee stability. My DAW is old and underpowered, but very stable. The few times I've encountered consistent issues were due to bad audio interface firmware, bad RAM, plugins with known issues, or very specific, repeatable SONAR bugs that were generally fixed in the next release (like the recent one with drum maps in project templates).