I have latency issues when playing VST i's through the Focusrite interface. I don't have any issues with my ZOOM interfaces and I had this problem even before Band Lab took over so it has to be a problem within the software. It is safe to say it is not my setup because I don't have any latency issues with any other DAW I use.
 
Any suggestions? 
Thanks for any help.

What Focusrite unit do you have?  Maybe someone has an answer but the many different Focusrite models we need to know what Focusrite you have.

I also have problems at times with latency using my Scarlett AI when I play my midi keyboard through the DAW.
You can fiddle with buffers and all that (search the forum for latency to find about a million suggestions). While this helps, for me it was not a 100% solution. You can also try the PDC button (Plugin Delay Compensation), which for me helped the latency, but seemed to mess up the timing of my tracks on playback.
Something I DO want to try, though, is based on what I read recently on the forum about how some effects will cause latency...this is all I know, and I planned on researching some more, but it sounded promising.
I do not play real-time along with my projects through the DAW all that often, so this has not been a huge issue for me...but it is annoying.

A few of us had audio dropout issues with Focusrite interfaces after one of the Windows 10 updates like the Anniversary update or something. Switching to a USB 2.0 port instead of a USB 3.0 port fixed that issue, believe it or not. If you think you have the right drivers installed, you could try that for your issue just in case.. 

There is nothing inherent about Cakewalk that would produce latency where other DAWs do not. More information is needed, like what driver you're using.
 
Meanwhile, create a new project with only the VSTi that appears to be causing issues, and see what happens.

I also had trouble with Focusrite latency and as an experiment I used the Magix low latency driver (I also own Samplitude) as the driver for Cakewalk and dropouts stopped and I was able to get a much lower latency.   I've never seen that before (and I've been recording since the days of t-dat 16 on windows 98), but it works wonderfully now.  

robbie111222
the Magix low latency driver

aka ASIO4All

I had the Focusrite 18i8 first generation which I talked with Focusrite directly and they provided me with a beta driver that worked for awhile. Then I updated Sonar and had problems again. I finally sent the 18i8 back to Sweetwater and they fixed the problem. I don't know what they did. Then I got a Focusrite 6i6 2nd Gen. and that has the same issues but both work fine in other DAWs. All drivers are current and up to date. My PC is running Windows 10. I guess the problem could be that Focusrite just doesn't play nice with Cakewalk. I also tried ASIO for all and that did not work.

Liquid Noise 23
I had the Focusrite 18i8 first generation which I talked with Focusrite directly and they provided me with a beta driver that worked for awhile. Then I updated Sonar and had problems again. I finally sent the 18i8 back to Sweetwater and they fixed the problem. I don't know what they did. Then I got a Focusrite 6i6 2nd Gen. and that has the same issues but both work fine in other DAWs. All drivers are current and up to date. My PC is running Windows 10. I guess the problem could be that Focusrite just doesn't play nice with Cakewalk. I also tried ASIO for all and that did not work.

The last time Focusrite sent me a beta driver for my gen 1 2i4 - it was to fix audio problems in Windows 10. Just playing any audio app at all. My issue wasn't related to DAWs. After the Windows 10 Anniversary update, I (and a few other users from a non-DAW related forum) were getting audio dropouts, too in Windows 10. Surprisingly, switching from a USB 3.0 port to a USB 2.0 port solved the issue. Something seemed to have changed after the Anniversary update. Now, my 2i4 bypasses all USB 3.0 ports on my PC tower case and goes directly to the USB 2.0 port on the motherboard.
It works perfectly with Cakewalk.

GjB
A few of us had audio dropout issues with Focusrite interfaces after one of the Windows 10 updates like the Anniversary update or something. Switching to a USB 2.0 port instead of a USB 3.0 port fixed that issue, believe it or not. If you think you have the right drivers installed, you could try that for your issue just in case.. 

I'm using the Focusrite Scarlett 18i20 on one PC and the 6i6 on another (both 1st gen). Strangely enough for me, I found that swapping from USB 2.0 to USB 3.0 solved most latency problems for me. I'm now running it at 2ms (well, at least that's what Scarlett MixControl tells me).
 
I tried the beta 1.8.3 version of MixControl, but this didn't help for me - I found it unstable and didn't improve latency. I've now been running v1.8.128 for over 2 years without issues on both Win10 64 and Win 7 64.
 
Have did had a few issues with some plugins with what appeared to be latency:

• Antares AVOX suite - VST3 is unusable at any setting, switching to VST2 solved all my issues and will happily run at 2ms.
• VirtualGuitarist VSTi's - At first I found I had to run these at 6ms, but I found clicking the "Load using JBridge" setting within Plugin Manager (still using the 64 bit plugin) solved this and I can happily run those at 2ms also.

 
M.