Why I always put NI's Vintage Organs in its own instance of Kontakt.
 
I have been use VB3 and some other options for a while but started a track using Vintage Organs. All good, then I added a couple other instruments and the organ stopped sounding, here's why.
 
VO was set to OMNI so it can receive upper manual on channel 1, lower on 2 and pedals on 3. My other instruments are using channels 4 and 5. OK until one of the notes (C0) on channel 5 corresponds to a keyswitch on VO which, being set to OMNI happily accepts it and changes to the all drawbars off setting. Guess who had not saved his carefully adjusted drawbar settings
 
If you are using VO put it in its own instance of Kontakt - you know it makes sense!

I have declared Martial Law in the studio and that is now the law of the land. I love when people share things like that. So smart and effective. Thanks Glyn.

 
The key switches are a real PITA.
Even with one instance of Kontakt, I get all excited, start flailing around and hit a forbidden key messing up everything. Garritan GPO4 has the same irritating setup.
Maybe there's a hidden tab in Kontakt to turn them off?