Sanderxpander
If your ASIO device supports multiple clients you could try loading both programs and A/B more effectively. Better yet, first match volumes and then have a family member alt+TAB and play back without you looking.
I use WDM when ever possible. I have thought of having someone else listen and will when I can. I did retry this today to check and it was the same as before. The file is stereo and the output is stereo. I double checked for plugins and found none.
To be completely candid the title is an exaggeration. The difference is much smaller but very noticeable. Putting a percentage on it is silly. I will look into this with greater care and detail.
Actually I am not happy to notice this. It means I have a problem with Samplitude. No other wave player such as Sound Forge gives any difference. Nor does Studio One or Reaper.