In Samplitude there appears to be different audio engines.
Below is from the Samplitude X2 Pro manual.
Hybrid Engine and Economy Tracks
Very small audio buffers ("Low latency" mode) increase the CPU strain of the
playback engine. For optimal use of the PC resources, we recommend using the mixer
tracks in "Low latency" mode only. This includes:
• Monitor tracks
• Tracks with VSTis
Tracks that play hard disk content (MIDI or audio files) may be taken out of "Low
latency" mode in the Hybrid Engine by assigning the "Economy" property to them.
These tracks will then use the play engine's buffer (VIP buffer size).
I have tried to figure out what all this actually means but I'm still looking.