You should have no problems with that setup Dan. Things to check....
Latest driver version from PreSonus.
Make sure you're using ASIO mode.
Make sure AudioBox is NOT set as the default device in Windows sound settings.
Reduce buffer size (in the driver settings)
AudioBox input is the clock master in Sonar.
Make sure there are no reverb (or similar) plugins that require (and set) huge latency in any tracks , especially on the Master bus.
Try a test using WDM, Sonar should tell you the response time when it does its analysis, but ASIO is the preferred option.
I know it works, my daughter has one.