Yes...
As Zargg said... I thought about that too... Or any abrupt start/end of room sound or such... Maybe needing clip fades?
Another item I might mention is that if you're using reverb if delay fx, they will start/stop abruptly at clip boundaries and not their programmed characteristics unless the clip lasts long enough beyond the event...
I typically use clip fx for special situations of corrective EQ/compression, but more often I automate track/bus fx to keep my cpu load down