Just another "everything working well here" post to add to the chorus. I'm running a Q9300 w/ 8GB RAM, 1GB ATI Radeon card, all 7200 RPM HDDs and Win7 x64. And with this, uh, "mature" setup, SPlat feels very similar to X3 overall. I also haven't noticed any real performance difference between one SPlat release and the next, and even that's subjective.
Maybe a few seconds here and there during initial project load, or it could be my level of patience at the time. Really hard to gauge.
Oh, and all of my projects include VSTi and audio, some leaning more towards one direction than other, but always a mix and always at least 3-4 VSTi; e.g., Kontakt, AD2, AK, DP/Rapture, etc., and lots of PC modules and FX Chains.