I have an update on the Focusrite Loopback. I got hold of Focusrite support and apparently, I am an idiot.
I thought I had done this, but you just need to set the audio drivers to not allow applications to take exclusive hold of the device.
This is a windows setting, not anything on the Focusrite mix panel. Right click the speaker in the system tray and select "playback devices". Select the Scarlett, properties, advanced, and uncheck "Allow applications to take exclusive control of this device". There's also the same setting in the record devices.
At any rate, after setting things up right, I can send machine out to any of the DAW outputs and use the loopback to run them through Sonar. I don't have Reason installed currently, but I would expect it to work the same way.
So, Loopback with the 8i6 works correctly and multiple applications can use the ASIO driver simultaneously.