Projects don't care where multisamples are loaded, it is all handled in the plug-ins.
For DPro move the "C:\Cakewalk\Dimension Pro\Mutlisamples" folder to "S:\DProMultisamples" (for example)
then run cmd.exe as administrator and type
mklink /j "C:\Cakewalk\Dimension Pro\Mutlisamples" "S:\DProMultisamples" Z3TA+2 is too small to worry about. Maybe look for the Cakewalk Sound Center and Session Drummer multisample folders and perform a similar move+mklnik operation on them, if you want to free up more disc space. RXP content folder is another GB which can be moved too. Also delete the Tutorial Projects from the "C:\Cakewalk Content SONAR" folders, if you do not elect to move Cakewalk Content. They are about 1GB each.