Thanks guys for all your interest and ideas but I have solved it .... or so far so good.
I don't know how the new aux busses work exactly .. you'd assume, just like any other buss, but no, they are a little bit weird.
I had all my drums routed to an aux buss with Pro Channel compressor on it in order to parallel compress the drums, however, it wasn't activated. I discovered that engaging the Input Echo button would allow the song to play without dropout. Disengage Input Echo on the buss, and the problem returned. Is this not strange behavior for a buss?
In the end I just deleted the aux buss, put my plugins back, and all is well ... so far.
Cheers.