If the issues go away when you toggle effects off, then it means one or more plugins effects in the project are adding a bunch of DPC latency, which you definitely do not want while recording. One or more than one of your plugins is likely doing some Look-Ahead processing, which will spike latency. Those types of plugins are really meant to be used in your project during MIXING/Mastering, and NOT while actually still doing tracking/recording.
So, please list all effects plugins this project has loaded, and I will try to help you figure out which ones to do something about.
Don't be alarmed by this, by the way. Once you start the mixing process, any if those plugins can be loaded in - you will just have to jack up your ASIO Buffer Size a BUNCH to make it big enough to handle the more lush effects. It is the nature of the beast - track/record with a smaller ASIO Buffer Size, and mix/master with a GIANT ASIO Buffer Size, and switch back and forth as you go from recording into mixing. for the rest of time.
Bob Bone