I have 6 HDDs in my machine
I do have 9 fans too!!
120mm exhaust
120mm on front of a triple HDD cage
80mm on front of other HDD cage
120mm on side over CPU [only 20mm profile :) ]
92mm on side cutout over GPU
2 x 120mm on CPU cooler (push/pull - huge Noctua heatsink)
80mm on GPU heatsink
80mm as general intake
I never get overheating problems.
It can get a bit noisy though!!
I generally use Noctua or Yate Loon fans which are generally very quiet.