I have a 76 key keyboard out all the time that I fiddle with. I'm much more comfortable on the guitar, but the keyboard is a challenge and a bit different from the guitar in the way you approach it.
One thing I kinda enjoy about the on-screen controller is that you can slide your finger across both black and white keys to create a fast chromatic run which is pretty easy on guitar, but a bit tougher on a real keyboard/piano. A run in the key is easy (just white keys) but to do chromatic is not the same.
I'm not sure it will ever matter, but it was an interesting thing to notice.
Also, I find it fun to try to play on the screen tunes I'm learning on piano. At times, I'm constrained by the width of my monitor, but using 1 hand, I can do just about anything I can play on a real keyboard. Perhaps not with the same level of expression, but it works pretty darn well.