tenfoot
If you are using a 3 pin AU plug it can be caused by an earth loop. I had the same problem using a Toshiba laptop. Lifting the ground on the power supply fixed it for me.

I wouldn't go lifting ground on any mains cable.  It's there for a reason, mostly to save your life.
 

I keep one of those ground lift plugs in my bag so that if I get ground issues I can lift one.
 
I agree you don't want to lift the only ground, but if you only have one, you shouldn't have a loop.

Paul P

tenfoot
If you are using a 3 pin AU plug it can be caused by an earth loop. I had the same problem using a Toshiba laptop. Lifting the ground on the power supply fixed it for me.

I wouldn't go lifting ground on any mains cable.  It's there for a reason, mostly to save your life.
 

 
Paul P.....As stated in the post above yours, you are not unearthing your entire system, simply removing a second ground that is causing the loop. Your circuit is still finding earth. If you do not understand how this works then you most definitely should not lift any ground!

Good ideas folks...after updating all video drivers, checking usb power settings, cleaning/checking a ton of connections, and experimenting with powered usb hubs, I found a suitable solution!
I installed a usb-3 card directly into a PCIE slot (per Craig A's note), bypassing all the Asus MB ports. Result, no HD/mouse noise! And there was much rejoicing let me tell you....gimmie that bottle!
I suspect that the Asus ports have some issue that allows this bleed through/interference.
Thanks for the responses, once again the awesome Forum hive mind has solved the problem, returning the Anomaly back to the source and saving Zion....

When USB was designed, it was to replace the Apple Desktop Bus and the PC's PS ports. No one cared about noise on the line because you didn't hear a mouse or printer. Like so many aspects of computers, they were not designed with pro audio and real-time streaming in mind. The separate card divorces the audio-related ports from the (usually) single controller that's feeding all your USB devices. In addition to getting rid of noise, I think you'll find an overall performance improvement with fewer "mystery glitches."
 
Maybe Cakewalk should bundle a USB port card with every copy of Platinum...

BE CAREFUL WHEN INSTALLING 3rd PARTY USB PCIe cards. 
 
I just blew a mobo so above solution scares me to death. 
It was not my DAW but my older office PC didn't have USB 3.0 so I ordered this PCIe card for $19 and installed it.  WIndows installed drivers fine but it didn't work. I then read the instructions ( duh) and found you had to plug in a 12V connector from your power supply. I guess this is the extras juice that USB 3 uses.  There was a standard old school power connector on the card so I did this. That was the end of that mobo... 
A little research on Google and I found many people had done the same thing....
 
So be super careful and might be better to add a USB 2.0 card and be safe. Audio interfaces are not using USB 3.0 anyhow so there's no gain. 
 
I have this same issue right now all of a sudden after I re arranged my equipment. I think you need to use the usb cables with the ferrite choke on them. I might have eliminated one because I needed some longer runs to my drum set. I'll see what happens when I unplug it. 
 

Cactus Music
BE CAREFUL WHEN INSTALLING 3rd PARTY USB PCIe cards. 
 
I just blew a mobo so above solution scares me to death. 
It was not my DAW but my older office PC didn't have USB 3.0 so I ordered this PCIe card for $19 and installed it.  WIndows installed drivers fine but it didn't work. I then read the instructions ( duh) and found you had to plug in a 12V connector from your power supply. I guess this is the extras juice that USB 3 uses.  There was a standard old school power connector on the card so I did this. That was the end of that mobo... 
A little research on Google and I found many people had done the same thing....
 
So be super careful and might be better to add a USB 2.0 card and be safe. Audio interfaces are not using USB 3.0 anyhow so there's no gain. 
 
I have this same issue right now all of a sudden after I re arranged my equipment. I think you need to use the usb cables with the ferrite choke on them. I might have eliminated one because I needed some longer runs to my drum set. I'll see what happens when I unplug it. 
 

I occasionally have audio glitches when moving the mouse (updated drivers on everything) and wondering if a usb cable with the ferrite choke on them would solve my issue.

IIRC Noel did a post about adding ferrite's to his studio equipment to kill hum. Might be worth a search.

I've had similar problems for weeks and opened a thread on this topic a few weeks back.
 
However, I found the solution to my problem on the Seven forums. The noise was being caused by an app called
Easy tune 6 which is a Gigabyte utility for CPU performance and management.
I uninstalled it in "uninstall a program" and it solved all my noise issues!!
 
For more info on that, the link to that solution is here http://www.sevenforums.co...-problems-my-daw.html.
 
Oh yes...I definately endorse using balance cables. Even with the noise problem present, using them cut the noise level down quite considerably.

That's cool - I have a hum caused by different circuits, and tried adding ferrite clips to inbound coax, but it didn't help my situation.
 
I believe I need to order up a ground-isolation insert for my coax.
 
Bob Bone