I would really like to be able to use multiple ASIO devices from different makers at the same time. My primary interface is a Tascam US-16x08. It's awesome.
However, I also have BOSS GT-001 that sports re-amping capability via USB, a THR10 with dry+wet pairs available via USB, and now a Laney IRT Studio with direct dry recording and re-amping support via USB. In order to use one of these, I have to take the 16x08 out - which has my monitors connected, blah, blah.
Anyway, you get the idea ...
Prior to getting the 16x08 I experimenting with aggregation via ASIO4ALL. It worked after much fiddling about, but the performance wasn't something I could live with. So I don't use the cool features some of my external hardware has.
The only way out of this that I can think of is to add a Mac to the mix for tracking with these other devices. But that would be expensive and I'm not sure if the alleged I/O aggregation capability of Mac really works as well in practice as the stories I've heard.
Maybe Windows 10 will address this.