Well, it's definitely an issue with VST3s in Sonar X3e, I didn't make this up, you know, and it only occurs with VST3s.
That being said, the problem could be caused by faulty plugins who do something to a side chain channel they shouldn't - as I described, it only occurs in larger projects.
Anyway it's not a problem for me, because the UR22 does not work with so low latency anyway (which is probably one of the causes of the problem). No need to troubleshoot anything, I'll just stay away from latency settings that my audio interface doesn't master. I merely wanted to warn other people to take extra care when trying out VST3 plugins with lower latency settings.