CTRL+S for saving the Project prior to closing it. Worth a try.
Another couple of things that come to mind:
1. In your motherboard's BIOS there may be more low-level options for the disk that can make a significant impact.
2. I do recall that replacing my ATAPI/IDE HDDs with SATA made a huge difference (as long as the motherboard has the SATA port-I think you have to slip-stream the SATA driver during the WinXP installation so that may not help in this case).
The usual tips:
A log off/log on may be necessary after making changes in DevMgr. Reboot is even better.
Defrag your disk.
Don't forget to read all the WinXP Audio Tweak Guides you can, i.e. this is vital:
Enable DMA mode for all hard disk drives (WinXP):
1. Check to make sure the transfer mode for your hard disk drive(s) is set to the DMA mode, otherwise the disk access speed will be poor.
2. Go to Control Panel > System > Hardware tab > Device Manager button. Expand the entry labeled IDE ATA/ATAPI controllers. Right click on the Primary IDE Channel item and select Properties and go to the Advanced Settings tab.
3. Check that the Transfer Mode options are set to DMA if available for all channels. Repeat this for all IDE channel items beneath IDE ATA/ATAPI controllers.