Thanks gentlemen. Sorry about leaving out the audio interface - it's an M-Audio Fast Track Pro.
I disabled all the plug-ins, although the Midi Effects (MFX) and Control Surfaces could not be disabled.
I also created exclusions for the Cakewalk folder under Program Files using Norton's "Items to Exclude From Scans" and "Items to Exclude from Auto-Protect, SONAR and Download Intelligence Detection.
However, X3 is still crashing.
While X3 was running, I did notice, by the way, that exporting to an mp3 now results in one file for each audio track, instead of one file with all, in this case 4, audio tracks in one song.