For Jayson: My text is the same size on both monitors.
I have found myself moving things to the bottom center of the 49" monitor as I need them. For example, if I am working in track view I just grab it and move it to where it is comfortable. If I need lyrics and console view I can put them side by side with lots of room to spare. I mostly use the 27" monitor to show synths, file browser and other desktop stuff. If I need that stuff I can grab it and put it on the 49" monitor for a second until I'm done with it, and then I put it back on the 27". Also, I have made the console and track views smaller than what you see in the jpeg I posted because I normally only use less than 15 tracks and busses. I can keep my X3 user's manual open on the 27" for reference
One downside is that I have to figure out a new place for my studio monitors because I now have a 37" Visio tv as a third monitor. Most of the time I just use the 37" as a tv on the side, muted of course. Also, I'm not happy with my boom placement for my microphone. It has become a question of where do you put hardware when you have these big monitors.
I'm very happy with my LG 49UB8500 tv and the Gigabyte GTX750 video card. If you are thinking of going this route, be careful about which tv and video card you get, and make sure all the inputs on the tv and outputs on the video card match your requirements. Also watch your computer power requirements. Some video cards need more than the 500 watts I have in my machine. A lot of info on the internet is out of date. My GTX750 box said it required 2 hdmi cables to do 60 hz (I am not a gamer), but when I plugged a single cable into the hdmi 3 port on the tv, the tv saw 60 hz. I might try using the other hdmi ports on the tv to see if they don't support 60hz also.