Every since upgrading to WINDOWS 10, I've been having drivers problems in Cakewalk Sonar, every time my computer goes into screensaver mode and sleep timer mode, when I wake up the computer some of my drivers are gone specifically the audio interface driver? It started doing this when I upgraded to windows 10, in windows 7 never had this problem. Anyone else ever had this problem?
 
Thanks

What happens if you disable the screensaver and sleep timer?  Set display to "always on"?  (Odds are you already tried this...)

Screensaver off, never sleep... standard DAW.
 

I have had similar behaviour with USB interfaces before and had to make sure to untick "Allow the computer to turn off this device to save power" in devicemanager and make sure even hidden items was visible to get to all of them.  
Not sure if this is the same with your PCI card but that is all I got :) 

Tobias beat me to it ^^^
 
Sometimes, USB ports don't revive properly after having been put to sleep.

Be sure to go through each device. I was a bit surprised how many had power management options, and by default, win10 was set to turn that device off. Leave the ‘wake up’ on for your keyboard and mouse !

Standard practice for any DAW computer is to set it so nothing ever goes to sleep and to disable any screen savers.

bdickens
Standard practice for any DAW computer is to set it so nothing ever goes to sleep and to disable any screen savers.

 ^ ^  This.

I had virtually the same problem when I got my new dell pc with WIN 10 in Jan, Feb.  Updates, restarting, each morning, whatever, the audio was gone. I just kept going thru the different lists for optimizing the pc and eventually, it stopped losing the drivers and I would have sound in the morning and even after restarting. I have always let my pcs go to sleep and I still do, I didn't know that was an issue. I can't say what solved it, but it wasn't the sleep nor the USB 3 port (mine were not set for disabling) because I kept those, but after a couple of weeks something must have worked in the settings and all seems good now for at least a month. The one horrible thing is windows updates because I never know when that is happening and all of a sudden in the middle of work the pc will stop functioning completely, can't even bring up control panel. I will attempt to restart and then it will tell me it is configuring updates. It often takes hours and then to restart will go black for about an hour, then restart and take about another hour to come to a login screen. It's a horrible experience. But I do have audio after that so OK, whatever, I guess there's nothing much more I can do. Your issue could well be what is mentioned above or maybe just some other setting like fast startup...I wish you well, it isn't fun to go through.

Ruben

bdickens
Standard practice for any DAW computer is to set it so nothing ever goes to sleep and to disable any screen savers.

^ ^  This.

+1. This is one of the first optimisations you should make. Also, make sure HDDs never sleep and that CPU never gets throttled.
 
I just have my screen set to turn off after 20 mins of inactivity and that hasn't caused any issues and just switches back on with a touch of the mouse, but don't use a screensaver! That's the only power saving feature I have enabled.