mettelus Folks who have taken the time to learn TH2 well tend to swear by it.
Yeah, I prefer TH2 over all, I have TH2 (of course) S-Gear, GTR, Revalver 3, 3.5 and 4, All Studio Devil stuff, AmpLion, All Amplitube stuff bar 6 stomp boxes (I think Amplitube is pretty much crapola, why did I buy all of it ? I ask myself that same question) Guitar Rig 3 and 5 (I consider it just below my opinion of Amplitube) and a heap of freebies, of which the only ones I use are Ignite amps and the Lepou stuff, both of which are excellent IMO, I use them with Rosen Digital cab's/impulse responses.
I almost always go straight for TH2, sometimes GTR, mess around with the others every now and then, but usually replace them pretty quickly with TH2. It just has the bases covered with effects etc, pretty comprehensive, and I like the sound and feel. S-Gear is awesome, just lacks the bells and whistles, the comprehensiveness of TH2. For me TH2 is where it's at, never really had an issue with the GUI, that's what it is, doesn't bother me