When you say "file", are you referring to the plugin layout or an individual plugin within the layout? If you're referring to the layout, you may still have to select it from the list of available layouts in the FX bin/browser/Pro Channel FX Chain. If you're referring to an individual plugin, I'm not sure this is the exact same issue, but, for me, Sonar periodically loads the wrong soft synth (never had the issue with effect plugins) after a project has been open for awhile. I've never reported it as exiting Sonar and relaunching has always resolved it - at least for that session.